Refolding of G-Protein-Coupled Receptors
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منابع مشابه
Refolding of Membrane Proteins
Nekrasova et al. “Overexpression, Solubilization and puri fication of rat and human olfactory receptors' Eur. J. Bio chem. (1996) 238: 28-37.* Kiefer, H., et al. (1996) Expression of an Olfactory Receptor in Escherichia coli: Purification, Reconstitution, and Ligand Binding. Biochemistry 35:10677-16084. Kiefer, H., et al. (1999) Refolding of G protein-coupled receptors from inclusion bodies pro...
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The factors defining the correct folding and stability of integral membrane proteins are poorly understood. Folding of only a few select membrane proteins has been scrutinised, leaving considerable deficiencies in knowledge for large protein families, such as G protein coupled receptors (GPCRs). Complete reversible folding, which is problematic for any membrane protein, has eluded this dominant...
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A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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تاریخ انتشار 2017